Getting My ceesdekker.net To Work
Getting My ceesdekker.net To Work
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Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular sorts with recombination perform.
‘It absolutely was basically a subject of selecting up a e-book on mobile biology and beginning to examine. I had originate from a planet of extremely-superior vacuums, cryostats and quantum phenomena, and now I had been Performing at area temperature with molecular biology kits.
Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on solitary molecules and metal clusters
2010, created a whole new way (‘wedging transfer’) to control nanostructures; to start with report of DNA translocation through graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en satisfied 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
What distinguishes biology from chemistry is usually that these elements with each other make up a living system. The secret of mentioned everyday living, I feel, lies within the interactions, the interaction of Those people molecules. The big concern concerning the origin of existence is still unanswered. How did we ever evolve from simple molecules into the really elaborate programs we see right now? We have no idea. I would like to operate on these kinds of significant, open questions.’
2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore complicated; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
‘Indeed, I have an understanding of folks were being shocked at enough time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I've to admit that it had turn into a little bit bored, I didn’t study Significantly anymore. The field went a lot more into the applying side, how you might integrate nanotubes into electronic circuits.
‘The fantastically delicate way during which components in nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I be expecting that my amazement with the complexity of creation will have amplified and with it my awe for that greatness in the Creator.’
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Numerous new phenomena were being uncovered, and he and his study team set up a number one placement in this subject of analysis. ceesdekker.net Dekker and his investigate group discovered new physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the 1st to construct a transistor dependant on an individual nanotube molecule.
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-selection conformational alterations in Mre11/DNA mend complexes; and initially drive measurements on the DNA molecule inside a nanopore
Solid-state nanopores have established to be a remarkably versatile probe for one-molecule Evaluation of DNA. I will describe a few of our latest results – exclusively DNA knots – and also our initiatives to grow the capabilities of strong-state nanopores even more, inside the way of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.